Sookie Stackhouse:. Main protagonist over all 7 seasons. A human / fairy hybrid and a telepath. She also has special fairy powers later in the show.
Sarah Newlin: Human, devout Christian. Wife of Steve Newlin and a leader of the Fellowship of The Sun, an anti-vampire Organisation. She is a secondary antagonist in the second season of the show and returns in the sixth season as a main antagonist. She stands behind the master plan to exterminate all vampires by contaminating Tru Blood with the Hepatitis V virus.
Jessica Hambly: A teenage girl in the first season, she is turned into a vampire by Bill. She becomes a main cast beginning with season 2.
Lorena Krasiki: Bill Compton’s maker and a beautiful female vampire. She is an antagonist in season 3.
Daphne Landry: During season two, she works as a waitress for Sam. She also becomes his love interest but is in fact a pawn of Maryann Forrester, the main antagonist of season 2.